An international team led by researchers at Baylor College of Medicine, Texas Children’s Hospital, McGill University and University of Pittsburgh School of Medicine has discovered what drives the growth of a lethal pediatric brain tumor called Posterior Fossa Type A (PFA) ependymoma. The researchers report in the journal Nature that androgens, commonly known as male … Read more
A multi-institutional study led by Mayo Clinic and published in Cell Reports Medicine reports that pairing a next-generation immunotherapy with standard hormone therapy before surgery may help overcome a long-standing barrier in early-stage prostate cancer treatment. Immunotherapy has been generally ineffective for prostate cancer because the tumors are considered immunologically “cold,” meaning they do not attract enough immune cells to mount a strong attack. Hormone therapy commonly used for prostate cancer, called androgen … Read more
Chemotherapy remains one of the most powerful tools in the fight against cancer, yet it often comes with significant long-term side effects that can dramatically affect patients’ quality of life. Among the most debilitating is Chemotherapy-Induced Peripheral Neuropathy, which impacts both the central and peripheral nervous systems and affects up to 85% of cancer patients … Read more
Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling, according to a preclinical study led by Weill Cornell Medicine investigators. The study was published on April 15 in Cell. “I was very surprised by our findings. … Read more
Erzsébet Merényi, a statistics research professor at Rice University, and co-investigators at The University of Texas MD Anderson Cancer Center Pratip Bhattacharya, professor of cancer systems imaging, and Dr. Patrick Pilié, assistant professor of genitourinary medical oncology, were awarded $1 million by the Cancer Prevention and Research Institute of Texas (CPRIT) to develop artificial intelligence … Read more
The androgen clock is rewriting the science of aging, offering a precise way to measure hormone exposure and its profound effects on health, longevity, and biology. Study: The androgen clock is an epigenetic predictor of long-term male hormone exposure. Image Credit: ivector / Shutterstock In a recent study published in the journal Proceedings of the National Academy … Read more