Bioinformatics

Experts chart path to bring microbiome science into routine clinical care

by

As researchers unlock the diagnostic and therapeutic promise of the human microbiome, a new roadmap highlights the urgent need for standardization, better evidence, and clinician education to transform patient care. Perspective: The microbiome for clinicians. Image Credit: Kateryna Kon / Shutterstock A recent perspective published in the journal Cell outlines the challenges, opportunities, and necessary actions to … Read more

Gene expression study reveals clues to asbestos-linked mesothelioma

by

Gene expression leading to alterations in the DNA caused by asbestos exposure may explain the development of Malignant Pleural Mesothelioma (MPM), a rare and aggressive cancer. By analyzing public RNA-seq data through a comprehensive bioinformatics pipeline, scientists working with the Sbarro Health Research Organization (SHRO) have developed an in-depth view of the molecular mechanisms involved … Read more

Therapeutic plasma exchange combined with intravenous immunoglobin reduces biological age

by

A first-of-its-kind clinical trial clinical trial shows that therapeutic plasma exchange (TPE) combined with intravenous immunoglobin reduced biological age on average by 2.6 years, as measured by multi-omic biomarkers. Results of the single-blind, placebo-controlled trial are published in the May 28, 2025, issue of Aging Cell, providing early data on the impact of TPE on … Read more

Precision Medicine for Soft Tissue Sarcomas | Improved Treatment

by

Revolutionizing Soft Tissue Sarcoma Treatment with Functional Precision Medicine Soft tissue sarcomas (STS) represent a formidable challenge in oncology. A recent collaborative study involving leading research institutions and a biotech firm has unveiled a promising new strategy for improving treatment outcomes for these rare and aggressive cancers. The findings, published in npj Precision Oncology, highlight … Read more

Platelet-rich plasma may enhance ovarian rejuvenation and improve egg quality in women

by

A new research paper was published in Aging (Aging-US) on February 18, 2025, Volume 17, Issue 2, titled “Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP).” Researchers from IVIRMA New Jersey, Yale School of Medicine, Yale University, and Acibadem Mehmet Ali Aydinlar University studied how a treatment called platelet-rich … Read more

New computational tool iDOMO improves prediction of drug synergy

by

Researchers at the Icahn School of Medicine at Mount Sinai have developed a powerful computational tool, named iDOMO, to improve the prediction of drug synergy and accelerate the development of combination therapies for complex diseases. The study, published in Briefings in Bioinformatics on February 20 [10.1093/bib/bbaf054], highlights iDOMO’s ability to identify synergistic drug combinations using gene expression data, outperforming … Read more

Exploring the Link Between Diet and Gene Expression in Fat Tissue

by

Here is the content you requested: Decoding fat tissue |​ EurekAlert! New research from ⁤the University ⁣of⁤ Delaware ⁢aims to ⁢tackle the issue by investigating obesity at the gene ⁢level.Principal investigator⁤ Ibra Fancher, assistant professor of kinesiology and applied physiology ⁢in UD’s ⁤College ⁣of Health sciences, discovered ⁢significant differences in gene expression in adipose tissue, … Read more

Study examines how diet impacts gene expression in fat tissue

by

As many as 40% of Americans are obese, putting them at an increased risk for high blood pressure, diabetes, stroke, heart disease and certain cancers, according to the CDC. New research from the University of Delaware aims to tackle the issue by investigating obesity at the gene level.  Principal investigator Ibra Fancher, assistant professor of kinesiology and … Read more

Immune gene expression changes in myocardial infarction revealed through bioinformatics

by

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at exploring immune-related genes and their expression changes in myocardial infarction (MI) through comprehensive bioinformatics methods and validating these genes as potential diagnostic and therapeutic targets. Gene expression data were analyzed from three datasets: GSE29111 and GSE66360, which were combined … Read more

Investigating fatty acid metabolism in hepatocellular carcinoma patients

by

Announcing a new publication for Acta Materia Medica journal. Fatty acid (FA) reprogramming has a significant role in liver cancer. However, the contribution of FA metabolism reprogramming to the heterogeneity of hepatocellular carcinoma (HCC) has not been established. This article describes how bioinformatics analysis using single-cell sequencing, a non-negative matrix factorization (NMF) algorithm, and survival … Read more