Lipid nanoparticles help CAR T cells melt pancreatic cancer barriers

Often diagnosed when surgery is no longer an option, pancreatic cancer is one of the most difficult cancers to treat and has one of the lowest rates of survival among major malignancies. Like many solid tumors, the most common type of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is shielded by the desmoplastic matrix-a dense barrier … Read more

UCF researcher explores insulin signaling as new target for diabetic neuropathy

Neuropathy – chronic pain, numbness and tingling in the hands and feet – is a challenging fact of life for many patients with Type 1 diabetes. Thanks to a new National Institutes of Health grant, a University of Central Florida (UCF) College of Medicine scientist is investigating a new approach to treat neuropathy without relying on … Read more

Brain injury protein in the blood could help estimate biological age in animals

The protein “neurofilament light chain” (NfL) – studied in humans in the context of neurodegenerative diseases and aging – is also detectable in the blood of numerous animals, and NfL levels increase with age in mice, cats, dogs, and horses. Experts from the DZNE and the Hertie Institute for Clinical Brain Research (HIH) at the … Read more

Onset of “the munchies” after cannabis use could offer clues to help people with appetite loss

The urgent onset of “the munchies” after cannabis use isn’t imaginary – it’s a cognitive response that occurs regardless of sex, age, weight or recent food consumption and could offer clues to help people struggling with appetite loss. Those findings from a collaborative study, conducted by researchers at Washington State University and the University of … Read more

Modern farming waste carries emerging contaminants that threaten ecosystems and health

A new scientific review highlights a growing environmental challenge linked to modern food production. Researchers report that waste from livestock and aquaculture operations now contains a complex mix of emerging contaminants that can spread through ecosystems and ultimately affect human health. The study synthesizes recent global research on so-called new contaminants, including antibiotic residues, antibiotic … Read more

New model reveals H5N1 is spreading undetected in US dairy herds

A powerful simulation of H5N1 transmission across 35,974 US herds shows that the virus is far more widespread than reported, raising urgent calls for better farm surveillance and stronger disease control. Study: A mathematical model of H5N1 influenza transmission in US dairy cattle. Image Credit: Clara Bastian / Shutterstock In a recent study in the journal Nature … Read more

Researchers secure funding to advance Chagas disease research

A team of researchers at Texas A&M University and the University of Georgia (UGA) has received more than $4 million from federal and non-governmental organizations to support research on Chagas disease prevalence, diagnostics and treatment to benefit both dogs and humans. Chagas disease is a tropical illness caused by the parasite Trypanosoma cruzi, which is most … Read more

Researchers to investigate new hepatitis B-like virus and its impact on cats

Photo: Stepan Popov/Adobe Stock With chronic hepatitis potentially being more common in cats than believed, according to a feline virologist at the City University of Hong Kong, a group of researchers and specialists are coming together to study the first hepatitis B-related virus found in carnivores. Specifically, their research will center on how the virus … Read more

Targeting a key protein outside of the brain could help manage Parkinson’s-related heart issues

Parkinson’s doesn’t just affect movement and the brain – it may also impact the heart, according to new research from the University of Surrey. Scientists from Surrey’s School of Veterinary Medicine suggest that targeting a key protein outside of the brain could help manage Parkinson’s-related heart issues. In a new study published in Experimental Physiology, … Read more

New project aims to help pin down the process of West Nile virus transmission

Mosquitoes have been transmitting the West Nile virus to humans in the United States for over 25 years, but we still don’t know precisely how the virus cycles through these pests and the other animals they bite. A federally funded project aims to help pin down the process by using mathematical models to analyze how … Read more