genes

Blood gene signals reveal Parkinson’s risk years before diagnosis

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Blood-based DNA repair and stress-response signals reveal a brief molecular window preceding Parkinson’s diagnosis. Study: Longitudinal assessment of DNA repair signature trajectory in prodromal versus established Parkinson’s disease. Image credit: Chinnapong/Shutterstock.com In a recent study published in npj Parkinson’s Disease, researchers examined DNA repair and integrated stress response (ISR) genes in healthy individuals and those … Read more

Sex-specific analysis uncovers unique disease pathways and treatment implications

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Biological differences between women and men led to variations in the appearance and progression of many diseases, which influenced diagnosis and response to treatments. These differences also affected the relationship between diseases, as they generated different combinations, risks, and patterns of joint appearance depending on sex. However, the biological mechanisms that explained these associations remained … Read more

ERC Proof of Concept grant supports promising CRISPR-based cancer treatment research

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Microbiologist John van der Oost of Wageningen University & Research (WUR) has received an ERC Proof of Concept grant to further develop a promising CRISPR-based approach to cancer treatment. With funding of €150,000, he and researcher Christian Südfeld will spend the next eighteen months working on a method to kill cancer cells from within, while … Read more

New mode of communication inside cells helps bacterial pathogens to evade drugs

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Biologists have uncovered a new mode of communication inside cells that helps bacterial pathogens learn how to evade drugs. Their findings, published in the journal Nature Communications, describe how these mechanisms drive antimicrobial resistance in Listeria monocytogenes, the foodborne bacteria that causes listeriosis.  The work is a collaboration between researchers at the University at Albany and … Read more

Study uncovers genes and proteins likely to play a causal role in Type 2 diabetes

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An international study co-led by researchers from the University of Massachusetts Amherst and Helmholtz Munich in Germany has uncovered hundreds of genes and proteins likely to play a causal role in Type 2 diabetes, many of which would have been missed by studies relying on blood samples alone. The study, published in Nature Metabolism, shows that … Read more

CUL5 & Tau: Brain Protein Protects Neurons From Damage

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Researchers at UC San Francisco have identified a hazardous waste collector in the brain that disposes of the toxic clumps of tau protein that can lead to dementia.… The post CUL5 & Tau: Brain Protein Protects Neurons From Damage appeared first on Archynetys. Source link

Brain protein CUL5 protects neurons by clearing toxic tau clumps

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Researchers at UC San Francisco have identified a hazardous waste collector in the brain that disposes of the toxic clumps of tau protein that can lead to dementia.  Neurons with more of this garbage collector, technically known as CUL5, are less vulnerable to Alzheimer’s disease.  The research helps explain how some brain cells may remain resilient even in advanced disease and points to new therapeutic strategies that could boost the brain’s natural defenses against neurodegeneration.  CUL5 is uniquely suited to getting rid … Read more

Study isolates mania-specific genetic architecture in bipolar disorder

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Researchers at King’s College London and the University of Florence have, for the first time, identified the specific genetic blueprint of mania, the defining feature of bipolar disorder. Bipolar disorder is one of the most severe and complex psychiatric conditions, affecting around 2% of people worldwide. While episodes of depression, psychosis and other symptoms are … Read more

First topical CRISPR gene therapy corrects disease-causing mutations in human skin

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Gene-editing tools like CRISPR have unlocked new treatments for previously uncurable diseases. Now, researchers at the University of British Columbia are extending those possibilities to the skin for the first time. The UBC team, together with researchers from the Berlin Institute of Health at Charité in Germany, has developed the first gene therapy capable of … Read more

Modern Lifestyles, Disrupted Gut Microbiome, Rising Disease Risk

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Archyde “`html The Gut-Sleep-Immunity Connection: How Modern Life Impacts Your Health The Delicate Balance Between Sleep, The Immune System And Gut Health Is Increasingly Recognized As A Cornerstone Of Overall wellbeing.… You can read the full story here: Modern Lifestyles, Disrupted Gut Microbiome, Rising Disease Risk. Source link