Australian researchers have developed a powerful new way to target deadly, drug-resistant bacteria by designing antibodies that recognize a sugar found only on bacterial cells – an advance that could underpin a new generation of immunotherapies for multidrug resistant hospital-acquired infections. Published in Nature Chemical Biology, the research shows that a laboratory-made antibody can clear … Read more
By analyzing tissue from patients with Parkinson’s disease, and animal and cellular models of the disease, a research team from the Institut de Neurociències of the UAB has shown that the main immune cells of the brain become reactive and overexpress certain receptors that promote the elimination of dopaminergic neurons, even when these neurons are … Read more
New results from a clinical trial co-led by UCLA investigators demonstrate how treating desmoplastic melanoma, a rare and aggressive skin cancer, with immunotherapy before surgery can dramatically shrink or even eliminate tumors, sparing patients from more aggressive surgeries and preserving their quality of life. The findings, published in Nature Cancer, show that 71% of patients … Read more
Scientists at the Icahn School of Medicine at Mount Sinai have identified an important immune response that helps explain why some cancer patients benefit from immunotherapy while others do not. In a study published in the January 27 online issue of Nature Medicine (DOI 10.1038/s41591-025-04177-6), the researchers found that antibody-producing immune cells called IgG1 plasma … Read more
When lung cancer treatment stops working, what happens next? New research reveals the answer may depend on how the cancer grows. Medical researchers at Flinders University have uncovered an important clue that could help doctors better predict what happens next for people with advanced lung cancer when their first treatment fails. Researchers looked at thousands … Read more
A landmark UK study involving tens of thousands of families has shown that childhood screening for type 1 diabetes is effective, laying the groundwork for a UK-wide childhood screening program. Results from the first phase of the ELSA (Early Surveillance for Autoimmune diabetes) study, co-funded by charities Diabetes UK and Breakthrough T1D, are published today in The Lancet Diabetes & Endocrinology. The findings mark a major step towards a … Read more
Oncologists have achieved some immune system responses in patients with pancreatic cancers using various combinations of vaccines and immune checkpoint inhibitor drugs, but it’s not always clear which therapy is inducing what type of response. To help drive further study, investigators from the Johns Hopkins Kimmel Cancer Center have made public a free, web-based atlas … Read more
Results from a phase 3 clinical trial published in the New England Journal of Medicine, today (June 2nd) show that patients with lung cancer who received an immunotherapy drug, nivolumab, along with standard chemotherapy before surgery had improved long term survival compared to those who received chemotherapy alone, at 5 years after completing treatment. Prof. Patrick Forde of … Read more
When cancer spreads from a primary tumor to new sites throughout the body, it undergoes changes that increase its genetic complexity. A new study from researchers at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center (MSK) provides fresh insights about how cancers evolve when they metastasize – insights that could aid in developing strategies … Read more
An immunotherapy drug could help some cancer patients live years longer without the disease getting worse or coming back, a trial has found. Pembrolizumab, sold under the brand name Keytruda, kept head and neck cancers at bay for five years compared to 30 months with standard care. It also slashed the risk of the disease … Read more