Triglyceride-lowering drug olezarsen fails to reduce arterial plaque

Despite experiencing significant reductions in triglycerides, patients with triglycerides over 150 mg/dL and a high risk of atherosclerosis did not experience any significant change in the amount of non-calcified plaque in their coronary arteries after taking the triglyceride-lowering drug olezarsen, in a one-year sub-study presented at the American College of Cardiology’s Annual Scientific Session (ACC.26). … Read more

Clinicians show modest response to elevated lipoprotein levels in low-risk patients

Elevated Lipoprotein(a) [Lp(a)] is an independent, genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD), with levels >50 mg/dL affecting 20–30% of the global population. Despite therapeutic limitations, interest in Lp(a) has increased, driven by its prognostic value and the emergence of targeted therapies. However, with increasing guideline-directed Lp(a) testing, clinician response to elevated concentrations, … Read more

Diabetic nephropathy shows severe biochemical abnormalities

Background and objectives Chronic diabetes mellitus is marked by hyperglycemia and metabolic dysfunction, increasing the risk of complications such as nephropathy. This study aimed to evaluate key biochemical parameters among participants with diabetic nephropathy (DNp), diabetes control (DC), nephropathy control (NC), and healthy control groups. Methods A prospective case-control study was conducted with 200 participants … Read more

South Asian adults in the U.S. have higher prevalence of risk factors for heart disease

South Asian adults in the U.S. report doing many of the right things for heart health, yet they show significantly higher rates of prediabetes, diabetes and hypertension than white and Chinese adults, and higher than or roughly similar rates to Black and Hispanic patients, according to a new study led by Northwestern Medicine. In a … Read more

Unprocessed beef does not worsen metabolic health in prediabetes

A controlled crossover trial finds that short-term consumption of unprocessed beef is on par with poultry for glucose control, β-cell function, and cardiometabolic markers in people with prediabetes. Study: Effects of Diets Containing Beef Compared with Poultry on Pancreatic β-Cell Function and Other Cardiometabolic Health Indicators in Males and Females with Prediabetes: A Randomized, Crossover … Read more

Health benefits and risks uncovered

A new review finds that while the carnivore diet may deliver short-term improvements, weak evidence and emerging risks make long-term adherence a gamble for health. Study: Carnivore Diet: A Scoping Review of the Current Evidence, Potential Benefits and Risks. Image Credit: Fascinadora / Shutterstock.com In a recent review published in Nutrients, researchers determined the nutritional adequacy … Read more

Research uncovers new links between blood lipid profiles and risk of developing Alzheimer’s

People who are at higher risk for heart disease also seem more likely to develop dementia. And research led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has discovered new associations between various lipid, or fat, levels in the blood and the risk of developing Alzheimer’s disease, the … Read more

Portfolio diet delays heart risk and lowers cholesterol in young adults

New research shows that even modest adherence to the Portfolio Diet, a plant-based cholesterol-lowering strategy, can significantly reduce cardiovascular risk factors in young adults and may postpone heart disease onset by more than a decade. Study: Portfolio diet and LDL-C in a young, multiethnic cohort: cross-sectional analyses with cumulative exposure modeling. Image Credit: Chiociolla / Shutterstock University … Read more

Digital lifestyle program cuts diabetes risk by 46% in prediabetics, study of 130k+ adults reveals

Could a 45-minute weekly digital coach be the key to reversing diabetes? New study of 130k+ adults shows dramatic risk reduction and remission rates, without pills or extreme diets. Study: Lifestyle Modification in Prediabetes and Diabetes: A Large Population Analysis. Image Credit: RSplaneta / Shutterstock In a recent article published in the journal Nutrients, researchers in the … Read more

Study reveals hidden cardiovascular risks in real-world low-carb diets

A new study reveals that while low-carb, high-fat diets may spare saturated fats and carbs from blame, high cholesterol and salt intake still threaten heart health—urging smarter food choices even in trendy diets. Study: Low carbohydrate high fat-diet in real life; A descriptive analysis of cardiovascular risk factors. Image Credit: 19 STUDIO / Shutterstock In a recent … Read more