Sleeping for 7 hours and 18 minutes every night may be the sweet spot for warding off the risk of insulin resistance-the precursor to type 2 diabetes-suggests a large observational study published in the open access journal BMJ Open Diabetes Research & Care. But weekend catch-up sleep is associated with a heightened risk of impaired glucose … Read more
The above-described methodology resulted in a multi-dimensional framework for a gNBS program consisting of 18 screening criteria (Table 1) assigned to two overarching categories and four subcategories: (A) Criteria that enable transparent disease selection: I. Four clinical criteria, II. Four diagnostic criteria, and III. Three therapeutic-interventional criteria … Source link
Tirzepatide is one of the drugs that has revolutionized the treatment of obesity and other conditions such as diabetes in recent years. Despite its clinical success, its precise molecular and cellular mechanisms are still not fully understood. A study in mice shows that the drug has a direct impact on improving metabolism by activating brown … Read more
A multidisciplinary team has uncovered a key mechanism that allows the human bacterium Mycoplasma pneumoniae-responsible for atypical pneumonia and other respiratory infections-to obtain cholesterol and other essential lipids directly from the human body. The discovery, published in Nature Communications, was co-led by Dr. Noemí Rotllan, from the Sant Pau Research Institute (IR Sant Pau) and … Read more
In vitro experiments Table of Contents In vitro experiments biochemical binding assay LXR GAL4 reporter transient transfection assays ABCA1 and SREBP1c luciferase reporter assays Human primary hepatocyte culture mendelian randomization… The post LXR Inverse Agonist for Dyslipidemia: Clinical Trial Results appeared first on News Directory 3. Source link
Multi-tissue metabolomics in the C26 mouse model of cachexia reveals large cachexia-specific alterations in the metabolite profiles We performed metabolomics from multiple tissues and the tumour in the well-established Colon 26 (C26) mouse model of cachexia (upon subcutaneous injection of C26 colon carcinoma cells)20. We assessed mice in either the pre-cachectic (before onset of weight … Read more
From your pantry to your gut: Scientists reveal how everyday food additives could silently fuel allergies, gut disorders, and chronic inflammation. Review: Food additives and their impact on human health. Image Credit: nau2018 / Shutterstock In a review article published in the journal Allergologia et Immunopathologia, researchers discussed the potential health impacts of various food additives, with a … Read more
Archyde Sweet Truth: Sugar-Sweetened Beverages Fuel Metabolic Disorders, Groundbreaking Study Reveals Table of Contents 1. Sweet Truth: Sugar-Sweetened Beverages Fuel Metabolic Disorders, Groundbreaking Study Reveals 2. The hidden Cost of Sweetness: A Deep Dive into SSB Consumption 3. unpacking the Research: How SSBs Damage Your Body 4. The Small Intestine’s Central Role 5. Fed vs. … Read more
Researchers at the Advanced Research Unit on Metabolism, Development & Aging (ARUMDA), in the Tata Institute of Fundamental Research (TIFR, Mumbai and TIFR Hyderabad), have unveiled a comprehensive understanding of the harmful effects of sugar-sweetened beverages (SSBs) on human health, using a preclinical mouse model that closely mimics human consumption patterns. The study, published in … Read more
Scientists weigh in on sugar substitutes—can low and no-calorie sweeteners (LNCSs) really support weight loss and blood sugar control, or do they have hidden metabolic effects? Front-of-package labels around the world. Reprinted with permission from the Global Research Program at UNC-Chapel Hill. In a recent review published in the journal Nutrients, researchers analyzed the role … Read more