TOPLINE: Compared with a conventional ad libitum Mediterranean diet, an energy-restricted Mediterranean diet along with physical activity helped preserve bone mineral density (BMD) during weight loss in older women with metabolic syndrome, showing the most benefits at the lumbar level over a 3-year period. METHODOLOGY: Individuals with obesity and older adults exhibit increased vulnerability to … Read more
TOPLINE: Switching from a boosted protease inhibitor (bPI)–based regimen to bictegravir plus emtricitabine plus tenofovir alafenamide (B/F/TAF) maintained virological suppression over 48 weeks in patients with HIV who had preexisting resistance to nucleoside reverse transcriptase inhibitors (NRTIs), however with increased adverse events. METHODOLOGY: This phase 4 trial assessed the safety and efficacy of switching from … Read more
TOPLINE: Patients with celiac disease have a twofold higher risk for developing any chronic liver disease than the general population, with the risk remaining elevated beyond 25 years after diagnosis. METHODOLOGY: A recent meta-analysis reported that approximately one fifth of patients with celiac disease have elevated aminotransferase levels, potentially signaling underlying liver injury or risk … Read more
This research was funded by the National Key R&D Program of China, China Dairy Industry Association Dairy Science and Technology Innovation Fund – Mengniu Special Research Support Project, and Major cooperation projects between Chinese Academy of Engineering and local authorities. It aimed to evaluate the effects of the probiotic Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) … Read more
Practiced for centuries as a ritual in many religions, intermittent fasting (IF) is rapidly growing in popularity as a weight loss and health-improvement tool. A 2024 survey found that as many as 13% of Americans followed an IF regimen during the previous year. But does it really offer health benefits? And are there any downsides? … Read more
As glucagon-like peptide 1 (GLP-1) receptor agonist use becomes more prevalent, patients are using them for new indications — and at new dosages. Say hello to microdosing, or taking doses lower than the recommended therapeutic amount, for various reasons: Weight maintenance, metabolic health improvements, anti-inflammation and anti-autoimmune effects, fewer side effects, and lower costs. Advocates … Read more
International researchers have uncovered potentially diagnostic gut microbiome signatures and metabolic pathways associated specifically with ulcerative colitis (UC) and Crohn’s disease (CD). Targeted droplet digital polymerase chain reaction (ddPCR)‒based quantification of bacterial species led to convenient inflammatory bowel disease (IBD) diagnostic assays that “are sufficiently robust, sensitive and cost-effective for clinical application,” the investigators wrote … Read more