Cardiovascular diseases (CVDs) continue to dominate global mortality statistics, with immune dysregulation emerging as a central feature in their pathogenesis. This review by Gareev et al. focuses on immune-derived microRNAs (immuno-miRs) as pivotal modulators of immune responses in cardiovascular settings, highlighting their roles in pathophysiology, diagnostic potential, and therapeutic promise. Introduction … Read more
A landmark study uncovers how a specific lung gene, FOXP4, raises the risk of persistent symptoms after COVID-19, providing fresh insight into why some people are more susceptible to long COVID than others. The 24 studies contributing to the Long COVID HGI data freeze 4 served as the discovery cohorts for the GWAS meta-analyses. Each … Read more
Treating migraine before the pain starts: New research shows ubrogepant eases premonitory symptoms, offering hope for millions seeking earlier and more effective relief. Study: Ubrogepant for the treatment of migraine prodromal symptoms: an exploratory analysis from the randomized phase 3 PRODROME trial. Image Credit: GoodStudio / Shutterstock The most recent exploratory analysis from the phase 3 PRODROME … Read more
Polycystic ovary syndrome (PCOS) represents a significant health concern for women of reproductive age, manifesting as a complex endocrine disorder with diverse clinical presentations. Characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, PCOS affects 5% to 20% of women and stands as a leading cause of anovulatory infertility. The pathophysiology of PCOS involves abnormal … Read more
Despite heightened obstetric risks, pregnant women may face a lower chance of developing Long COVID—findings that challenge assumptions and call for deeper insight into the immune landscape of pregnancy. Study: Long COVID after SARS-CoV-2 during pregnancy in the United States. Image Credit: Natalia Deriabina / Shutterstock In a recent study published in the journal Nature Communications, researchers … Read more
Archyde Unraveling Monkeypox: Epidemiology, Pathogenesis, and Future Directions Monkeypox, now frequently referred to as mpox, remains a public health concern, notably in understanding its zoonotic origins and evolving epidemiology. This article delves into the latest research, offering insights into the virus’s transmission, potential reservoirs, and strategies for prevention and treatment. The Enigma of the natural … Read more
Mani S, Ganesan A, Arunagiri T, Ravi Kumaran V, Kannaiah KP, Vellapandian C, Chanduluru HK. Epidemiology, virology, and mutation landscape of monkeypox virus from past to present. Cureus. 2024. https://doi.org/10.7759/cureus.67872. Article PubMed PubMed Central Google Scholar Bryer J, Freeman EE, Rosenbach M. Monkeypox emerges on a global scale: a historical review and dermatologic primer. J … Read more
Endometriosis, a prevalent gynecological condition, is characterized by the growth of endometrial-like tissues outside the uterus, leading to severe pain and infertility in affected women. The pathogenesis of endometriosis remains elusive, and effective treatments are limited, highlighting the need for a deeper understanding of its molecular mechanisms. A pivotal role of P21-activated kinase 5 (PAK5) … Read more