Research

Purdue researchers discover new therapeutic target for triple-negative breast cancer

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A Purdue University team led by Kyle Cottrell has discovered a new therapeutic target for triple-negative breast cancer. “Triple-negative breast cancer is a particularly deadly form of breast cancer that currently lacks targeted therapies,” said Cottrell, an assistant professor of biochemistry. Cottrell, biochemistry graduate student Addison Young and their co-authors describe the discovery in the journal RNA. The … Read more

Antibody-producing plasma cells shape effectiveness of PD-1 immunotherapy

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Scientists at the Icahn School of Medicine at Mount Sinai have identified an important immune response that helps explain why some cancer patients benefit from immunotherapy while others do not. In a study published in the January 27 online issue of Nature Medicine (DOI 10.1038/s41591-025-04177-6), the researchers found that antibody-producing immune cells called IgG1 plasma … Read more

Immune system dysfunction may fuel progressive heart failure after heart attacks

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When the heart’s muscle is weakened or injured due to a heart attack, it can make it hard for the heart to pump enough blood to meet the body’s needs. Over time, it can lead to heart failure, where the heart’s function drops below 40%. The condition affects an estimated 6.7 million people over the … Read more

Richer social environments linked to better cognitive health in aging adults

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Research by an interdisciplinary team from McGill University and Université Laval provides new insights into the links between social factors and cognitive health among aging adults. While previous research had found positive correlations between specific measures of social connectedness and a variety of health outcomes, this study appears to have been the first to create … Read more

UVA Data Science researcher leads $4.7M project for AI-powered diabetes management

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University of Virginia School of Data Science researcher Heman Shakeri has been awarded a major new research grant to lead work at the intersection of machine learning and diabetes care. Shakeri will serve as a contact PI alongside Dr. Greg Forlenza, pediatric endocrinologist at the University of Colorado Anschutz Medical Campus (Barbara Davis Center for Diabetes). The … Read more

Scientists offer new insight into how common parasite T. gondii causes disease

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A University of California, Riverside team of scientists has found that Toxoplasma gondii, a common parasite affecting up to one-third of the global population, is far more complex than previously believed. The findings, published in Nature Communications, offer new insight into how T. gondii causes disease and why it has been so difficult to treat. Humans commonly contract toxoplasmosis by … Read more

Financial incentives lower blood sugar in uncontrolled type 2 diabetes

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Background: In this randomized controlled trial in Israel, researchers examined whether a contingent discount as a financial incentive on medication expenses could help people with poorly controlled type 2 diabetes better manage their blood sugar. The study included 186 adults from neighborhoods with low socioeconomic status and followed them for six months. Intervention participants received … Read more

Not all children with autism benefit from early language therapy

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A large-scale study reveals why some autistic children remain minimally verbal despite intensive early intervention, and what factors may shape more personalized support. Study: Proportion and Profile of Autistic Children Not Acquiring Spoken Language Despite Receiving Evidence-Based Early Interventions. Image credit: Prostock-studio/Shutterstock.com A recent study in the Journal of Clinical Child and Adolescent Psychology investigated … Read more

KAIST proposes novel strategy for multifactorial Alzheimer’s treatment

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Conventional treatments of Alzheimer’s disease, one of the most common forms of dementia, have been largely focused on targeting individual pathological features. However, Alzheimer’s disease is a multifactorial disorder driven by multiple, tightly interconnected processes, rendering single-target therapeutic approaches inherently limited. Addressing this challenge, KAIST researchers propose a new strategy that enables the simultaneous regulation … Read more

Blood protein albumin identified as key defense against deadly black fungus

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A new international study published in Nature has identified albumin, the most abundant protein in human blood, as a powerful and previously unrecognized defense against mucormycosis, a rare but often fatal fungal infection. The research was led by George Chamilos, MD and his laboratory at the University of Crete and Institute of Molecular Biology and Biotechnology, with critical contributions from a Lundquist Institute for Biomedical … Read more