Digital decision support tool improves outcomes in colorectal surgery

Research published in The Lancet Gastroenterology & Hepatology provides robust evidence for the use of a digital visualization and decision support tool in colorectal (bowel) surgery. This is the first time that a digital decision support tool has been conclusively proven to significantly improve outcomes in this type of surgery. Colorectal cancer is the third … Read more

Targeted mRNA delivery restores sperm production and fertility in infertile mice

Researchers have found that targeted delivery of messenger RNA (mRNA) can restore sperm production and fertility in genetically infertile male mice. The findings, published today in Stem Cell Reports, demonstrate that transient mRNA treatment restored sperm production and enabled the birth of healthy offspring. Up to 10% of couples worldwide are affected by infertility, according … Read more

Unexpected function of gene network in gut microbes revealed

Could a gene regulatory network in gut microbes have evolved its elaborate and tightly regulated molecular machinery only to pump out antibiotics indiscriminately? Researchers from the Institute of Science and Technology Austria (ISTA) show this is an auxiliary function. By maintaining basal levels of genetic activity when the network is in its OFF state, these … Read more

Blocking an inflammatory receptor in the retinas of aging mice improves retinal health

A new research paper was published in Aging (Aging-US) on January 31, 2025, in Volume 17, Issue 2, titled “Cysteinyl leukotriene receptor 1 modulates retinal immune cells, vascularity and proteolytic activity in aged mice.” The study, led by first author and corresponding author Andreas Koller from the University Hospital of the Paracelsus Medical University, found that blocking an inflammatory receptor … Read more

Advancements in molecular diagnostics for hematopoietic and lymphocytic neoplasms

Hematopoietic and lymphocytic neoplasms (HLNs) are a diverse group of malignancies affecting blood and lymphatic systems, with outcomes varying from manageable conditions to fatal diseases. Traditional classifications rely on morphology, karyotyping, and fluorescence in situ hybridization (FISH). However, recent advancements in next-generation sequencing (NGS) allow simultaneous genetic profiling of multiple genes, enhancing diagnostic precision and … Read more

AI-based technology accelerates discovery of new tuberculosis drug candidates

Tuberculosis is a serious global health threat that infected more than 10 million people in 2022. Spread through the air and into the lungs, the pathogen that causes “TB” can lead to chronic cough, chest pains, fatigue, fever and weight loss. While infections are more extensive in other parts of the world, a serious tuberculosis … Read more