Steatosis

New algorithm enables precise subtyping of metabolic liver disease

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Metabolic-associated steatotic liver disease (MASLD) is a clinically heterogeneous condition with highly variable outcomes affecting more than 30% individuals globally. The disease is conventionally staged by histological progression, ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and ultimately fibrosis or cirrhosis. Beyond liver-related outcomes, MASLD significantly elevates the risk of extrahepatic complications, including cardiovascular … Read more

EVA1A regulates fatty acid transporter CD36 in fatty liver disease

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Metabolic Dysfunction-Associated Steatotic Liver Disease（MASLD） is characterized by excessive accumulation of lipids in hepatocytes and is closely associated with the rapid rise in insulin resistance, obesity, and diabetes prevalence, making it one of the most common chronic liver diseases worldwide. Fatty liver can lead to systemic metabolic dysfunction and further progress to steatohepatitis, hepatic fibrosis, … Read more

How are GLP-1 drugs reshaping treatment for obesity, diabetes, and heart disease?

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A sweeping Lancet review reveals how modern incretin-based drugs are reshaping treatment for obesity and diabetes, delivering powerful weight loss while simultaneously protecting the heart, kidneys, and metabolic health. Review: GLP-1 receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits. Image Credit: Gecko Studio / Shutterstock In a recent review published in The … Read more

Excessive Screen Time Linked to Higher Liver Steatosis Risk in Adolescents

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Excessive screen time is associated with an increased risk of liver steatosis in adolescents, according to findings from a recent study.1 Leveraging data from National Health and Nutrition Examination Surveys (NHANES) 2017-2018 participants 12–17 years of age, the study found ≥ 5 hours of self-reported screen time per day was linked to a greater risk of … Read more

Excessive Screen Time Linked to Higher Liver Steatosis Risk in Adolescents

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Excessive screen time is associated with an increased risk of liver steatosis in adolescents, according to findings from a recent study.1 Leveraging data from National Health and Nutrition Examination Surveys (NHANES) 2017-2018 participants 12–17 years of age, the study found ≥ 5 hours of self-reported screen time per day was linked to a greater risk of … Read more

Impact of excessive alcohol consumption on digestive health

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Excessive alcohol consumption is a significant public health concern, responsible for approximately 6% of all deaths and contributing to 5.1% of the global disease burden. Alcohol use is a major risk factor for over 200 diseases, including liver cirrhosis, pancreatitis, and esophageal cancer, with a particularly high incidence of gastrointestinal diseases. More than 50% of … Read more

Study reveals the role of transcription factors as therapeutic gateways in MAFLD

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Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions worldwide. This complex liver disorder ranges from simple steatosis to more severe forms, including metabolic dysfunction-associated steatohepatitis (MASH), which may progress to fibrosis, cirrhosis, and even liver cancer. The latest insights into transcription factors provide a deeper understanding of the … Read more

Vitamin E significantly improves liver health in MASH patients, new study finds

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New research shows that Vitamin E therapy significantly enhances liver function and reduces inflammation in MASH patients, providing a safer and effective treatment option in the fight against metabolic liver disease. Study: Vitamin E (300 mg) in the treatment of MASH: A multi-center, randomized, double-blind, placebo-controlled study In a recent study published in the journal Cell Reports … Read more

Understanding the mechanisms behind alcohol-associated liver disease

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A newly published review in eGastroenterology compiles recent research on alcohol-associated liver disease (ALD), offering an overview of its pathogenesis and efforts to better understand this condition. ALD, caused by excessive alcohol consumption, remains a significant contributor to liver-related mortality worldwide. Effective treatments are still limited, underscoring the need for a deeper understanding of its … Read more