Researchers from Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (Penn Medicine) have successfully employed an algorithm to identify potential mutations which increase disease risk in the noncoding regions our DNA, which make up the vast majority of the human genome. The findings could serve as the … Read more
Brazilian researchers reveal that even mild cases of COVID-19 can temporarily reduce heart rate variability, with stress on the autonomic nervous system lasting up to six months—especially in older individuals. Study: Impact of COVID-19 on heart rate variability in post-COVID individuals compared to a control group. Image Credit: Swetochka / Shutterstock.com Several studies have reported that … Read more
For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously “undruggable” cancer protein target, permanently blocking it. Transcription factors are proteins that act as ‘master switches’ of gene activity and play a key role in cancer development. Attempts over the years to design “small molecule” drugs that block them … Read more
Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions worldwide. This complex liver disorder ranges from simple steatosis to more severe forms, including metabolic dysfunction-associated steatohepatitis (MASH), which may progress to fibrosis, cirrhosis, and even liver cancer. The latest insights into transcription factors provide a deeper understanding of the … Read more
This new review article highlights the crucial role of GATA6, a transcription factor, in pancreatic ductal adenocarcinoma (PDA). The article explores GATA6’s dual role in cancer progression and its potential as a biomarker and treatment target. Pancreatic cancer remains one of the deadliest malignancies, with a five-year survival rate of only 5%. This study finds … Read more
Nearly 60,000 people are diagnosed with oral cancer in the U.S. every year, according to the American Cancer Society, and the rate of new cases continues to rise. Now, researchers at University of California San Diego have discovered how healthy stem cells are transformed into cancer stem cells in the earliest stages of the disease. … Read more
A new study reveals that even low-dose, chronic exposure to air pollution can trigger liver inflammation, fibrosis, and metabolic disruptions, increasing the risk of fatty liver disease and other hepatic disorders. Study: Mouse study demonstrates liver damage from low-level PM2.5 exposure. Image Credit: Shutterstock AI Generator / Shuttersotck.com A recent study published in the Journal of … Read more
Understanding the Role of Fam102a in Bone Remodeling Bones are the dynamic tissue that forms the skeleton, enabling physical movements. They maintain their structural integrity through a process… The post Understanding Bone Remodeling: The Role of Fam102a in Osteoblast and Osteoclast Differentiation appeared first on NewsyList. Source link
Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements. The structural integrity of bones has been attributed to bone remodeling-aa highly regulated process of bone formation and bone resorption (dissolving old and damaged bones), driven by osteoblast and osteoclast bone cells, respectively. An … Read more
Research reveals how the dietary flavonoid promotes regulatory T cell development and suppresses inflammation through key immune pathways. Study: Kaempferol Exerts Anti-Inflammatory Effects by Accelerating Treg Development via Aryl Hydrocarbon Receptor-Mediated and PU.1/IRF4-Dependent Transactivation of the Aldh1a2/Raldh2 Gene in Dendritic Cells. Image Credit: Danijela Maksimovic/Shutterstock.com In a recent article published in the Allergy, a group of researchers studied … Read more