Cell Proliferation

Vitamin D curbs colorectal cancer by boosting immunity and blocking tumor growth

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Vitamin D’s anti-cancer powers go beyond bones, new findings reveal how it suppresses inflammation, boosts immune surveillance, and disrupts tumor development to guard against colorectal cancer. Study: Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications. Image Credit: crystal light / Shutterstock.com A recent study in the journal Nutrients reviews the role of vitamin … Read more

Study reveals ferulic acid’s potential in preventing colon cancer

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Colon cancer continues to be one of the leading causes of cancer-related deaths worldwide, with poor dietary habits identified as a major risk factor. Ferulic acid, a phenolic compound abundant in many plant foods, has previously demonstrated potential anti-cancer properties by inhibiting cell proliferation and promoting apoptosis. Despite its promising effects, the impact of ferulic … Read more

E64FC26 inhibits inflammation and joint destruction in rheumatoid arthritis models

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Background and objectives Protein disulfide isomerases (PDIs) are essential enzymes that facilitate the proper folding of proteins and maintain protein quality within the endoplasmic reticulum. Dysregulation of PDIs has been correlated with numerous disorders, including cancer and rheumatoid arthritis (RA). E64FC26 (EFC), a small molecule that inhibits a wide range of PDI family members, has … Read more

Inflammasome protects stem cells from becoming cancerous

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A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators. The study, published Jan. 2 in Nature Immunology, may lead to therapies that target the earliest … Read more