Metastasis, the spread of cancer from a primary tumor to other parts of the body, is difficult to study in the lab, in part because researchers lack reliable ways to recreate the conditions cancer cells encounter as they travel through the bloodstream. Rice University bioengineers report a new platform designed to streamline one of the … Read more
Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide, largely due to metastasis and limited responses to immunotherapy in most patients. Although immune checkpoint inhibitors have transformed treatment for certain tumor subtypes, the majority of colorectal cancers remain “immune-cold,” meaning they fail to trigger effective anti-tumor immunity. Increasing evidence suggests that tumor-associated … Read more
Researchers at the University of Gothenburg have identified a protein linked to an increased risk of metastasis and recurrence in lung cancer. The findings are presented in a study that paves the way for new precision medicine approaches, particularly for older patients. Lung cancer primarily affects older individuals. Despite this, many laboratory studies rely on … Read more
Until now, the following has been true for metastatic pancreatic cancer: Once the tumor has spread, local treatment such as surgery is usually no longer an option. In recent years, however, studies have suggested that there is a small group of patients with a limited number of metastases (oligometastases) who can benefit from a combination … Read more
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have found that depleting a clotting protein made by the liver could slow down pancreatic cancer. The research, recently published in Gastroenterology and led by Melissa L. Fishel, PhD, shows that reducing fibrinogen in mouse models shrinks primary pancreatic ductal adenocarcinoma (PDAC) tumors and reduces their ability to … Read more
A recent study published in Engineering has shed light on a novel therapeutic target for improving anti-angiogenic treatment in colorectal cancer (CRC). The research, conducted by an international team of scientists from institutions including Sun Yat-sen University and The Chinese University of Hong Kong, identified the RNA N⁶-methyladenosine (m⁶A) reader insulin-like growth factor 2 mRNA-binding … Read more
A recent integrative analysis of single-cell sequencing and single-cell spatial mapping of lymph node metastasis in breast cancer reveals novel mechanisms of the metabolic-immune interaction that drive the spread of breast cancer. The findings from the study in The American Journal of Pathology, published by Elsevier, offer novel insights into the characteristics of the metastatic … Read more
Original story from King’s College London How breast cancer is detected can impact a patient’s chance of survival, with screening, even at a late stage, associated with a greater likelihood of surgical intervention. Women with stage IV breast cancer detected through screening have a 60% chance of survival ten years after diagnosis. This is in comparison … Read more
A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating an immune response or toxicity-related side effects. Researchers constructed tiny molecular clusters called RNA micelles, loaded them with potent chemo drugs and an … Read more
Researchers at Baylor College of Medicine have uncovered a strategy that triple negative breast cancer (TNBC) cells use to boost their ability to metastasize, or spread to other organs. Metastasis is the leading cause of cancer-related deaths and scientists are investigating ways to prevent it. These findings, published in Nature Communications, highlight new possibilities for … Read more