Portal hypertension (PH), a serious complication of liver cirrhosis, is defined as a pressure gradient > 5 mmHg between the portal vein and the inferior vena cava. When the hepatic venous pressure gradient (HVPG) exceeds 10 mmHg, the condition becomes clinically significant, and complications rise substantially, making early detection critical for guiding treatment. A recent … Read more
Bottom Line: A machine learning model that analyzes patient demographics, electronic health record data, and routine blood test results predicted a patient’s risk of hepatocellular carcinoma (HCC), the most common type of liver cancer, with high accuracy. Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research … Read more
Metabolic-associated steatotic liver disease (MASLD) is a clinically heterogeneous condition with highly variable outcomes affecting more than 30% individuals globally. The disease is conventionally staged by histological progression, ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and ultimately fibrosis or cirrhosis. Beyond liver-related outcomes, MASLD significantly elevates the risk of extrahepatic complications, including cardiovascular … Read more
Metabolic Dysfunction-Associated Steatotic Liver Disease（MASLD） is characterized by excessive accumulation of lipids in hepatocytes and is closely associated with the rapid rise in insulin resistance, obesity, and diabetes prevalence, making it one of the most common chronic liver diseases worldwide. Fatty liver can lead to systemic metabolic dysfunction and further progress to steatohepatitis, hepatic fibrosis, … Read more
Researchers at the Johns Hopkins Kimmel Cancer Center report that an artificial intelligence (AI)-based liquid biopsy test using genome-wide cell-free DNA (cfDNA) fragmentation patterns and repeat landscapes can detect early liver fibrosis and cirrhosis, and may also reveal signals of broader chronic disease burden. The research was supported in part by the National Institutes of Health, and … Read more
Researchers from The University of Osaka find that chronic liver congestion is linked to severe liver diseases through a specific signaling pathway in liver sinusoidal endothelial cells – key cells lining the liver’s tiny blood vessels. The long-term stasis of blood in the liver, known as chronic liver congestion, can lead to a range of … Read more
A new study reveals that the predictive power of key inflammatory markers, such as C-reactive protein, shifts fundamentally depending on whether a patient suffers from cirrhosis or acute/chronic coronary disease. Measured using an electrocardiogram, ventricular repolarization, which refers to the duration of time the heart muscle takes to electrically “reset” after each beat, is the … Read more
Background and aims Bacterial infections (BIs) are common and severe complications in patients with liver cirrhosis, but global data are limited. Here, we aimed to evaluate the global prevalence, temporal changes, and associated mortality risk of BIs in liver cirrhosis. Methods We systematically searched PubMed, Embase, Web of Science, and the Cochrane Library for eligible … Read more
Groundbreaking advancements in MASH cirrhosis treatment are rapidly emerging.Discover how GLP-1 and FGF21 analogs are reshaping the landscape of liver disease management,offering renewed hope for those affected. Recent studies highlight the potential of these novel drug therapies to significantly improve outcomes and revolutionize patient care. This article dives deep into the science, exploring the mechanisms … Read more
Photo: Stepan Popov/Adobe Stock With chronic hepatitis potentially being more common in cats than believed, according to a feline virologist at the City University of Hong Kong, a group of researchers and specialists are coming together to study the first hepatitis B-related virus found in carnivores. Specifically, their research will center on how the virus … Read more