A multiomic atlas of the aging human hippocampus uncovers how epigenetic regulation of neural stem cells and immature neurons may shape cognitive decline or resilience in later life. Study: Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease. Image Credit: MP Art / Shutterstock In a recent study published in the journal Nature, researchers delineated neurogenesis … Read more
Research in Aging Cell indicates that blood levels of particular small non-coding RNAs, which regulate gene expression, may influence how long a person lives. Investigators evaluated 828 small non-coding RNAs in blood samples from 1,271 community-dwelling older adults 71 years of age and older who were participating in an ongoing study. They then used machine … Read more
A new study sheds light on the behavior of yeast cells in the gut, paving the way for new lines of yeast that more efficiently produce therapeutic drugs tailored to address specific diseases. “Yeast is promising as a drug-delivery platform,” says Nathan Crook, corresponding author of the study and an associate professor of chemical and … Read more
Researchers led by Xian-Yang Qin at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have developed a score that predicts the risk of liver cancer. Published in the scientific journal Proceedings of the National Academy of Sciences, the study establishes that the protein MYCN drives liver tumorigenesis, specifically of the type of tumors found … Read more
Renowned as first responders to threatening infections, neutrophils also happen to feature prominently in the microenvironment of tumors, where they and other immune cells play opposing and frequently mutable roles in promoting-or resisting-cancer progression. Though they’ve been linked to the growth of multiple cancers, including those of the lung and breast, neutrophils can assume multiple … Read more
Blood-based DNA repair and stress-response signals reveal a brief molecular window preceding Parkinson’s diagnosis. Study: Longitudinal assessment of DNA repair signature trajectory in prodromal versus established Parkinson’s disease. Image credit: Chinnapong/Shutterstock.com In a recent study published in npj Parkinson’s Disease, researchers examined DNA repair and integrated stress response (ISR) genes in healthy individuals and those … Read more
Children born to mothers who are very obese with a BMI of 35 or higher are at heightened risk of being admitted to hospital for an infection, finds a long term study published in the open access journal BMJ Medicine. The findings highlight the importance of maintaining a healthy body weight before and after the pregnancy, … Read more
Gene expression leading to alterations in the DNA caused by asbestos exposure may explain the development of Malignant Pleural Mesothelioma (MPM), a rare and aggressive cancer. By analyzing public RNA-seq data through a comprehensive bioinformatics pipeline, scientists working with the Sbarro Health Research Organization (SHRO) have developed an in-depth view of the molecular mechanisms involved … Read more
Cardiovascular diseases (CVDs) continue to dominate global mortality statistics, with immune dysregulation emerging as a central feature in their pathogenesis. This review by Gareev et al. focuses on immune-derived microRNAs (immuno-miRs) as pivotal modulators of immune responses in cardiovascular settings, highlighting their roles in pathophysiology, diagnostic potential, and therapeutic promise. Introduction … Read more
Aedes aegypti mosquitoes in Florida are most resistant to a common insecticide around dusk but most susceptible between midnight and dawn, a new study finds. A key contributing factor observed by researchers is that five key genes that produce detoxifying enzymes in the mosquitoes are affected by changes in light over 24-hour cycles. Here, a … Read more