Malaria Turns Down Genes to Evade Immunity, Enable Chronic Infection

Researchers at Weill Cornell Medicine have discovered how Plasmodium falciparum, the parasite that causes malaria when transmitted through a mosquito bite, can hide from the body’s immune system, sometimes for years. The team’s preclinical study showed that the parasite can shut down a key set of genes, rendering itself “immunologically invisible.” Their results indicate that … Read more

Malaria parasite found to evade the immune system by shutting down key genes

Researchers at Weill Cornell Medicine have discovered how a parasite that causes malaria when transmitted through a mosquito bite can hide from the body’s immune system, sometimes for years. It turns out that the parasite, Plasmodium falciparum, can shut down a key set of genes, rendering itself “immunologically invisible.” “This finding provides another piece of … Read more

Multi-omics analysis uncovers molecular drivers of non-viral liver cancer development

Researchers discover that inflammation and aging contribute to non-viral liver cancer development. Green tea’s role in reversing some of the pathway dysregulation that may contribute to the cancer development and other therapies explored.  Liver cancer can arise spontaneously from healthy liver tissue. Recently, however, researchers have discovered an increasing correlation between some liver cancers and … Read more

Study identifies a new key factor contributing to aggressive nature of pancreatic cancer

Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates-only 10% after five years. One of the factors contributing to its aggressiveness is its tumor microenvironment, known as the stroma, which makes up the majority of the tumor mass and consists of a network of proteins and different … Read more

New study connects parasitic disease to genetic changes in the cervical lining

New research has revealed that Schistosoma haematobium (S. haematobium), a parasitic infection affecting millions globally, can trigger cancer-related gene activity in the cervical lining, with changes becoming even more pronounced after treatment. Presented today at ESCMID Global 2025, this pivotal study sheds new light on how this often-overlooked parasitic disease may contribute to cervical cancer risk … Read more

Asthma Genetics: New Study Reveals Key Findings

Archyde Genetic Map of Asthma Unfolds: Chicago Researchers Identify key Differences Between Adult and Childhood Onset Table of Contents 1. Genetic Map of Asthma Unfolds: Chicago Researchers Identify key Differences Between Adult and Childhood Onset 2. Decoding the Asthma Genome: A New Approach 3. Childhood vs. Adult-Onset: Two Distinct genetic Pathways 4. Fine-mapping for Future … Read more

Certain nasal bacteria could affect COVID-19 vulnerability

A new study from researchers at the George Washington University has found that certain bacteria living in the nose may influence how likely someone is to get a COVID-19 infection. Published in EBioMedicine, the research reveals that certain types of nasal bacteria can affect the levels of key proteins the virus needs to enter human … Read more

Unexpected function of gene network in gut microbes revealed

Could a gene regulatory network in gut microbes have evolved its elaborate and tightly regulated molecular machinery only to pump out antibiotics indiscriminately? Researchers from the Institute of Science and Technology Austria (ISTA) show this is an auxiliary function. By maintaining basal levels of genetic activity when the network is in its OFF state, these … Read more

How your skin’s microbes shape immunity, inflammation, and chronic skin disease

From babyhood to adulthood, the bacteria and fungi on your skin help train your immune system—but when that balance tips, chronic inflammation can follow. This new review reveals how and why. Study: Conversation between skin microbiota and the host: from early life to adulthood. Image Credit: Corona Borealis Studio / Shutterstock In a recent review published in … Read more

Targeting PCSK9 and APOA4 for the treatment of TMAO-induced cholelithiasis

Background and aims Cholesterol synthesis and gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is a metabolite of gut microbiota. However, the underlying mechanisms of TMAO-induced lithogenesis remain incompletely understood. This study aimed to explore the specific molecular mechanisms through which TMAO promotes gallstone formation. Methods Enzyme-linked immunosorbent assays were used … Read more