A team of researchers from the Institute for Neurosciences, a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche, in collaboration with researchers from Columbia University (New York, USA), has identified a mechanism that regulates the production of two different proteins from the same gene. This discovery, … Read more
Study highlights how PCOS alters uterine lining | Image Credit: © Pakorn – © Pakorn – stock.adobe.com. Differences in uterine lining composition The composition of cells and gene expression in uterine lining differ between women with polycystic ovary syndrome (PCOS) vs those without PCOS, according to a recent study published in Nature Medicine.1 Investigators developed … Read more
Only recently has the ribosome – one of the oldest molecular machines in evolutionary terms – been recognized as an active regulator of gene expression at the level of protein biosynthesis. This is an important process for the development and function of cells, in which genetic information is converted into proteins. The final step, in … Read more
Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions worldwide. This complex liver disorder ranges from simple steatosis to more severe forms, including metabolic dysfunction-associated steatohepatitis (MASH), which may progress to fibrosis, cirrhosis, and even liver cancer. The latest insights into transcription factors provide a deeper understanding of the … Read more
Air pollution contributes to nearly 7 million premature deaths each year, and its effects go far beyond the lungs. Breathing in wildfire smoke or automobile-related city smog doesn’t just increase the risk of asthma and heart disease-it may also contribute to brain diseases as diverse as Alzheimer’s and autism. Scientists at Scripps Research have discovered … Read more
NIH study reveals key players underlying disease onset and repair. Using an animal model of multiple sclerosis (MS), researchers at the National Institutes of Health (NIH) have created a four-dimensional brain map that reveals how lesions similar to those seen in human MS form. These findings, published in Science, provide a window into the early … Read more
Researchers at the Icahn School of Medicine at Mount Sinai have developed a powerful computational tool, named iDOMO, to improve the prediction of drug synergy and accelerate the development of combination therapies for complex diseases. The study, published in Briefings in Bioinformatics on February 20 [10.1093/bib/bbaf054], highlights iDOMO’s ability to identify synergistic drug combinations using gene expression data, outperforming … Read more
Using a new technology and computational method, researchers from Fred Hutch Cancer Center and The University of Texas MD Anderson Cancer Center have uncovered a biomarker capable of accurately predicting outcomes in meningioma brain tumors and breast cancers. In the study, published today in Science, the researchers discovered that the amount of a specific enzyme, … Read more
Aging is a privilege, but it also brings risks-including an increased likelihood of developing age-related diseases including cancer. Researchers at The Jackson Laboratory (JAX) have created a landmark atlas of how healthy breast tissue ages, revealing key cellular, molecular, and genetic changes that may tip the balance toward breast cancer development. Their findings, published recently … Read more
Using a new technology and computational method, researchers from Fred Hutch Cancer Center and The University of Texas MD Anderson Cancer Center have uncovered a biomarker capable of accurately predicting outcomes in meningioma brain tumors and breast cancers. In the study, published today in Science, the researchers discovered that the amount of a specific enzyme, … Read more