Mouse Model

KAIST proposes novel strategy for multifactorial Alzheimer’s treatment

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Conventional treatments of Alzheimer’s disease, one of the most common forms of dementia, have been largely focused on targeting individual pathological features. However, Alzheimer’s disease is a multifactorial disorder driven by multiple, tightly interconnected processes, rendering single-target therapeutic approaches inherently limited. Addressing this challenge, KAIST researchers propose a new strategy that enables the simultaneous regulation … Read more

Gene therapy targeting connexin 43 shows promise across inherited heart diseases

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Jan 26 2026 University of California San Diego-led team has discovered that restoring a key cardiac protein called connexin‑43 in a mouse model can dramatically improve heart function and extend survival in several inherited forms of arrhythmogenic cardiomyopathy (ACM). The research suggests that a single gene therapy might someday help a wide range of ACM … Read more

New mouse model sheds light on smell loss and neural regeneration

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A new study suggests that stem cells thought to be dormant may offer clues to why our sense of smell declines or is lost. Using a newly devised, three-dimensional model to study the regeneration of nerve tissue in the nose, researchers at Tufts University School of Medicine and the Graduate School of Biomedical Sciences (GSBS) and colleagues have discovered … Read more

JAX study sheds light on infection vulnerability in patients with rare mitochondrial diseases

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Patients with rare mitochondrial diseases already face a host of serious health issues, from muscle weakness to neurological problems and heart conditions. But one of their most life-threatening challenges has remained a mystery-why are they so vulnerable to severe infections? Now, scientists at The Jackson Laboratory (JAX) may have finally pinpointed why. Their new study, … Read more

Researchers find immune system proteins involved in severe cases of schistosomiasis

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New insights into the mechanisms that cause more severe cases of schistosomiasis – a disease caused by parasitic worms and second only to malaria in terms of potential harm – have been revealed by researchers at Penn State. The study – which took place in mice and was published in PLOS Pathogens -used a mouse model to examine how the … Read more

Scientists stop long-COVID symptoms in mice using a new antiviral compound

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A groundbreaking preclinical study reveals how targeting a viral enzyme with a new drug could prevent long-COVID complications, offering hope for millions and a powerful tool for future coronavirus threats. Study: A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID Over 77 million people globally have experienced lingering symptoms after recovering from … Read more

Tim-3 identified as promising therapeutic target for Alzheimer’s disease

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Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in Nature, researchers from Mass General Brigham used preclinical models to uncover Tim-3’s role in microglia, the brain’s resident immune cells, and have … Read more

Study links linoleic acid to triple-negative breast cancer growth

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Linoleic acid, an omega-6 fatty acid found in seed oils such as soybean and safflower oil, and animal products including pork and eggs, specifically enhances the growth of the hard-to-treat “triple negative” breast cancer subtype, according to a preclinical study led by Weill Cornell Medicine investigators. The discovery could lead to new dietary and pharmaceutical … Read more

Unveiling the Health Risks: New Study on Sugar-Sweetened Beverages’ Impact on Health

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Archyde Sweet Truth: Sugar-Sweetened Beverages Fuel Metabolic Disorders, Groundbreaking Study Reveals Table of Contents 1. Sweet Truth: Sugar-Sweetened Beverages Fuel Metabolic Disorders, Groundbreaking Study Reveals 2. The hidden Cost of Sweetness: A Deep Dive into SSB Consumption 3. unpacking the Research: How SSBs Damage Your Body 4. The Small Intestine’s Central Role 5. Fed vs. … Read more

Study offers new insights into the harmful effects of sugar-sweetened beverages on human health

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Researchers at the Advanced Research Unit on Metabolism, Development & Aging (ARUMDA), in the Tata Institute of Fundamental Research (TIFR, Mumbai and TIFR Hyderabad), have unveiled a comprehensive understanding of the harmful effects of sugar-sweetened beverages (SSBs) on human health, using a preclinical mouse model that closely mimics human consumption patterns. The study, published in … Read more