HP can induce cells to undergo LDCD Mechanical force can be divided into two categories: mechanical positive pressure (PP) and hypobaric pressure (HP), due to positive and negative loading, respectively. We used mesenchymal stem cells (MSCs) as a cell source to study the mechanism of mechanical force-induced cell death. Surprisingly, HP treatment induced MSCs to … Read more
Archyde: Latest World News, Economy, Entertainment, Health, Technology & Sports Updates Necrosis: Unlocking Secrets of Cell Death to Combat Aging and Disease London, United kingdom – Groundbreaking research illuminates how necrosis, a form of cell death, could revolutionize our approach to… You can read the full story here: Necrosis: Key to Longevity & Space Health?. … Read more
Cardiovascular diseases (CVDs) continue to dominate global mortality statistics, with immune dysregulation emerging as a central feature in their pathogenesis. This review by Gareev et al. focuses on immune-derived microRNAs (immuno-miRs) as pivotal modulators of immune responses in cardiovascular settings, highlighting their roles in pathophysiology, diagnostic potential, and therapeutic promise. Introduction … Read more
Measuring the density of a cell can reveal a great deal about the cell’s state. As cells proliferate, differentiate, or undergo cell death, they may gain or lose water and other molecules, which is revealed by changes in density. Tracking these tiny changes in cells’ physical state is difficult to do at a large scale, … Read more
A decade ago, University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington’s disease? They found that HTT is something like a traffic controller inside neurons, moving different cargo along neuronal highways called axons in concert with other proteins key for cellular function … Read more
Stanford Medicine researchers have developed a blood test capable of detecting cancers, the ways cancer resists treatments and tissue injury caused by non-cancerous conditions. The new test analyzes RNA molecules in the bloodstream. This type of RNA is called cell-free RNA because the tiny molecules no longer inhabit a cell. There are always fragments of … Read more
In a study of the immune systems of mice, scientists at Johns Hopkins Medicine say they have found a new role for a protein, QRICH1, which could become a target for drugs to dial up or down the activation of T cells to fight cancers and autoimmune diseases. The research was designed to advance development … Read more
Investigators at Mass General Brigham have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death. These results, published in Nature, could … Read more
Atrial fibrillation (AF) is a common form of heart arrhythmia, a serious condition in which the heart beats so fast that its upper chambers, the atria, quiver. This irregular heartbeat can increase the risk of severe conditions, including heart failure, dementia and stroke. My lab has been studying the role of inflammation in the initiation … Read more
A research led by Sergio P. Acebrón, Researcher Ikerbasque at the UPV/EHU, develops a key tool to visualize the immune response to abnormal DNA, opening new avenues for the treatment of diseases. The study, published in the prestigious journal EMBO Journal, reveals why some tumors escape the immune system, and offers a method to visualize … Read more