Consuming a high-fat diet can lead to a variety of health problems – not only weight gain but also an increased risk of diabetes and other chronic diseases. At the cellular level, hundreds of changes take place in response to a high-fat diet. MIT researchers have now mapped out some of those changes, with a … Read more
Acute coronary syndrome (ACS) in patients with SARS-CoV-2 infection represents a critical intersection of viral-induced inflammation and cardiovascular pathology. This review explores the dual mechanisms driving SARS-CoV-2-associated ACS and evaluates emerging therapeutic strategies, including phytomedicine and nanotechnology, to address both viral and cardiovascular complications. SARS-CoV-2 and ACS pathogenesis SARS-CoV-2 infection exacerbates ACS through systemic inflammation, … Read more
In a global first, scientists have used advanced base editing to repair a deadly gene mutation in a newborn, marking a major leap forward in the treatment of rare inherited metabolic diseases. Study: Personalized Gene Editing to Treat an Inborn Error of Metabolism. Image Credit: Shutterstock AI Generator / Shutterstock.com In a recent New England Journal … Read more
A new study uncovers how diabetic red blood cells release toxic packages that damage blood vessels, revealing a promising path for preventing serious complications. EVs derived from RBCs of patients with T2D are taken up by the endothelium and impair endothelium-dependent relaxation via an EV-mediated transfer of the prooxidant enzyme Arg1. Proteoglycan remodeling is a … Read more
Every living creature on Earth needs to protect itself from things that would do it harm. Bacteria are no different. And despite their relative simplicity, they deploy remarkably savvy defensive strategies against viral invaders. The most well-known is CRISPR-Cas9, adapted for human use as the first FDA-approved genetic editing technique. In the past year, researchers … Read more
Modified antibiotics beat a stubborn lung pathogen and dodge metabolic landmines, offering new hope for patients with HIV, cystic fibrosis, and TB co-infections. Study: Next-generation rifamycins for the treatment of mycobacterial infections. Image Credit: Kateryna Kon / Shutterstock The rise of drug-resistant bacteria is a major health crisis. Moreover, the development of antibiotic resistance in pulmonary pathogens … Read more
Parkinson’s disease (PD) is a neurodegenerative disorder in which the α-synuclein protein abnormally aggregates within brain cells, causing neuronal damage. Through international collaboration, researchers at KAIST have revealed that RNA editing plays a crucial role in regulating neuroinflammation, a key pathology of Parkinson’s disease. KAIST (represented by President Kwang-Hyung Lee) announced on the 27th of … Read more
By pinpointing how neuroestrogen directly boosts appetite-suppressing receptors in the brain, scientists are laying the groundwork for precision therapies that could tackle obesity from within the central nervous system. Study: Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake. Image Credit: r.classen / Shutterstock A study led by researchers at the Fujita … Read more
New research links high-fructose diets, especially from processed foods, to disrupted appetite signals and long-term brain changes, raising concerns for developing brains. Review: Mindful Eating: A Deep Insight Into Fructose Metabolism and Its Effects on Appetite Regulation and Brain Function. Image Credit: Oleksandra Naumenko / Shutterstock A recent review study published in the Journal of Nutrition and … Read more
A team at UC San Francisco and Gladstone Institutes has developed new drug candidates that show great promise against the virus that causes COVID-19 and potentially other coronaviruses… The post New Coronavirus Drug Candidates: Promising Research appeared first on NewsyList. Source link