Researchers have discovered that mutations in the FOXJ3 gene act as a “master switch” failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy. The study reveals how FOXJ3 controls the formation of brain cortical layers during brain development by regulating the PTEN–mTOR signaling pathway. The PTEN-mTOR … Read more
In recent years, rates of childhood obesity have been rising, with the U.S. Centers for Disease Control estimating in 2024 that approximately one in five children and adolescents met the clinical definition of obese. But preventing childhood obesity is a complex undertaking. While encouraging a healthy diet and adequate exercise have long been two strategies … Read more
Age is more than just one number. While neuroscientists used to think of cognitive aging as a single trendline, they now realize that vast individual differences require a more predictive and personalized approach. As they uncover more factors that affect cognition over time, they are realizing that modeling the aging brain requires more diverse data … Read more
Archyde The sensation of touch, from a gentle tap to the feeling of clothing against skin, relies on a complex network of nerve cells and specialized proteins. Scientists have long known… You can read the full story here: How PIEZO2 Senses Touch: New Insights into Molecular Mechanisms & Sensory Disorders. Source link
Neuroscientists at King’s College London have pinpointed a mechanism behind the increased neural connectivity observed in the very early stages of Alzheimer’s disease. Published in Translational Psychiatry, the study also demonstrated that a cancer medication has the potential to reduce this hyperconnectivity. The research, funded by Alzheimer’s Society and conducted in brain cells of rats, showed that low levels of the protein amyloid-beta could induce … Read more
A new study published in Neurology and led by Queen Mary University of London has revealed that people of South Asian, African , and European ancestry share many of the same genetic risk factors for multiple sclerosis (MS). This new study is one of the most ancestrally diverse genetic analyses of MS conducted in the UK. MS affects around 150,000 people in the UK and more than two million people … Read more
In little moments like when sipping coffee or licking an ice cream cone, it doesn’t seem like your body is pulling off a biological miracle. But it is. That cookie is not you-yet when you put it in your mouth, your body is able to tolerate it and process it without any detriment to your … Read more
A major study of US veterans suggests that GLP-1 diabetes medications may influence addiction-related outcomes, revealing a surprising connection between metabolic treatments and substance use risk. Study: Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study. Image Credit: Kotcha K / Shutterstock A recent study … Read more
A 12-year national study reveals that aging need not mean decline. Researchers show that many older adults maintain or even improve their cognitive and physical abilities, and that positive beliefs about aging are linked to better long-term health trajectories. Study: Aging Redefined: Cognitive and Physical Improvement with Positive Age Beliefs. Image Credit: Finist4 / Shutterstock … Read more
1. Background： With the increasing aging population, high incidence of chronic diseases, and the growing number of congenital or acquired foot deformities, lower limb dysfunction and abnormal gait problems are becoming increasingly common, posing a significant threat to public health and quality of life. Gait analysis is widely considered a sensitive biomechanical indicator for evaluating … Read more