Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling, according to a preclinical study led by Weill Cornell Medicine investigators. The study was published on April 15 in Cell. “I was very surprised by our findings. … Read more
Cleveland Clinic virology researchers have found that a specific protein modification to the immune protein MDA5 is key to how human bodies detect and respond to viruses and viral replication. The PNAS publication explains how two protein modifications activate MDA5, an essential immune protein, to sense invaders, limit viral replication and fight infections. This process is key … Read more
Oxford scientists propose that psychedelics could rewire brain circuits behind compulsive eating, offering a bold new strategy to treat obesity, if future trials confirm their potential. Review: The compulsive eating paradigm: can psychedelics help in treating obesity? Image Credit: Eskymaks / Shutterstock Psychedelics, a class of hallucinogenic drugs, may serve as a potential therapeutic intervention for some … Read more
A groundbreaking preclinical study reveals how targeting a viral enzyme with a new drug could prevent long-COVID complications, offering hope for millions and a powerful tool for future coronavirus threats. Study: A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID Over 77 million people globally have experienced lingering symptoms after recovering from … Read more
Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in Nature, researchers from Mass General Brigham used preclinical models to uncover Tim-3’s role in microglia, the brain’s resident immune cells, and have … Read more
A team of researchers from the Rice Biotech Launch Pad at Rice University has developed an implantable “cytokine factory” that safely triggers potent immune responses against hard-to-treat cancers, including metastatic melanoma, pancreatic and colorectal tumors. The study, published in The Journal of ImmunoTherapy of Cancer, details how an immunoprotected device near the tumor microenvironment containing cells … Read more
Alzheimer’s disease, the most common cause of dementia, is currently incurable. The current drugs available have very limited efficacy and only in mild stages of the disease. A team from the University of Barcelona has developed a promising therapeutic candidate to treat this disease, which affects more than 800,000 people in Spain. According to a … Read more
Linoleic acid, an omega-6 fatty acid found in seed oils such as soybean and safflower oil, and animal products including pork and eggs, specifically enhances the growth of the hard-to-treat “triple negative” breast cancer subtype, according to a preclinical study led by Weill Cornell Medicine investigators. The discovery could lead to new dietary and pharmaceutical … Read more
Archyde Sweet Truth: Sugar-Sweetened Beverages Fuel Metabolic Disorders, Groundbreaking Study Reveals Table of Contents 1. Sweet Truth: Sugar-Sweetened Beverages Fuel Metabolic Disorders, Groundbreaking Study Reveals 2. The hidden Cost of Sweetness: A Deep Dive into SSB Consumption 3. unpacking the Research: How SSBs Damage Your Body 4. The Small Intestine’s Central Role 5. Fed vs. … Read more
Researchers at the Advanced Research Unit on Metabolism, Development & Aging (ARUMDA), in the Tata Institute of Fundamental Research (TIFR, Mumbai and TIFR Hyderabad), have unveiled a comprehensive understanding of the harmful effects of sugar-sweetened beverages (SSBs) on human health, using a preclinical mouse model that closely mimics human consumption patterns. The study, published in … Read more