The Ontario Institute for Cancer Research (OICR) has announced its support for five Ontario research teams working to develop the next generation of medicines that kill tumours more effectively, cause fewer side effects and reduce the risk that cancer will come back. The projects will be funded as part of OICR’s Cancer Therapeutics Innovation Pipeline … Read more
Archyde New biomarkers Offer Hope for early kidney Injury Detection, Improving Patient Outcomes By Archyde News, March 31, 2025 Groundbreaking research from the Critical Path Institute (C-Path) and Boston Medical Center (BMC) reveals six biomarkers with the potential to revolutionize the early detection of drug-induced kidney injury, paving the way for safer medications and improved … Read more
Investigators at Mass General Brigham have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death. These results, published in Nature, could … Read more
Critical Path Institute® (C-Path) and Boston Medical Center (BMC) published results for six biomarkers that could improve the early and accurate detection of kidney injury, leading to both the development of safer medications and better health outcomes for all patients. The results leverage the collaborative expertise and investment of C-Path’s Predictive Safety Testing Consortium’s (PSTC) Nephrotoxicity … Read more
A new review was published in Oncotarget, Volume 16, on March 13, 2025, titled “Signaling pathway dysregulation in breast cancer.” In this review article, Dinara Ryspayeva and colleagues from Brown University provide a detailed look at how breast cancer cells change the way they communicate and grow-helping tumors survive, spread, and resist treatment. The review … Read more
Frederic L.W.V.J. Schaper, MD, PhD, director of Epilepsy Network Mapping at the Center for Brain Circuit Therapeutics at Brigham and Women’s Hospital and an instructor of neurology at Harvard Medical School, is the senior author of a paper published in Nature Communications, “A generalized epilepsy network derived from brain abnormalities and deep brain stimulation.” How … Read more
A drug-resistant type of bacteria that has adapted to health care settings evolved in the past several years to weaponize an antimicrobial genetic tool, eliminating its cousins and replacing them as the dominate strain. University of Pittsburgh School of Medicine scientists made the discovery when combing through local hospital data – and then confirmed that … Read more
In response to growing concerns over vaccine misinformation, declining public trust in science, and recent outbreaks of preventable diseases, a coalition of 34 scientific and medical organizations, led by the American Association of Immunologists (AAI) and the American College of Physicians (ACP), has issued a unified statement emphasizing the critical role of vaccinations in public … Read more
Fan Zhang, PhD, sees artificial intelligence as a pathway to finding an effective way to combat an intractable enemy: rheumatoid arthritis. Zhang is an assistant professor in the University of Colorado Department of Medicine’s Division of Rheumatology and also is affiliated with the Department of Biomedical Informatics on the CU Anschutz Medical Campus. She recently … Read more
Inside the human eye, the retina is made up of several types of cells, including the light-sensing photoreceptors that initiate the cascade of events that lead to vision. Damage to the photoreceptors, either through degenerative disease or injury, leads to permanent vision impairment or blindness. David Gamm, director of UW–Madison’s McPherson Eye Research Institute and professor of … Read more