Insulin resistance

Machine learning model demonstrates insulin resistance as a risk factor for 12 types of cancer

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Insulin resistance – when the body doesn’t properly respond to insulin, a hormone that helps control blood glucose levels – is one of the fundamental causes of diabetes. In addition to diabetes, it is widely known that insulin resistance can lead to cardiovascular, kidney and liver diseases. While insulin resistance is tightly associated with obesity, it has been difficult to evaluate insulin resistance itself in the clinic. For the first time, … Read more

Tirzepatide shows dual benefits in sleep apnea trial improving metabolism and reducing inflammation

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New clinical trial evidence suggests targeting both obesity and sleep-disordered breathing together may reshape cardiometabolic risk management in obstructive sleep apnea. Tirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial. Image Credit: Mongkolchon Akesin / Shutterstock In a recent study published in the journal Nature Medicine, researchers reported results from the … Read more

Engineered liver tissue model mimics early metabolic liver disease

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More than 100 million people in the United States suffer from metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by a buildup of fat in the liver. This condition can lead to the development of more severe liver disease that causes inflammation and fibrosis. In hopes of discovering new treatments for these liver diseases, MIT engineers … Read more

Unprocessed beef does not worsen metabolic health in prediabetes

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A controlled crossover trial finds that short-term consumption of unprocessed beef is on par with poultry for glucose control, β-cell function, and cardiometabolic markers in people with prediabetes. Study: Effects of Diets Containing Beef Compared with Poultry on Pancreatic β-Cell Function and Other Cardiometabolic Health Indicators in Males and Females with Prediabetes: A Randomized, Crossover … Read more

PFAS exposure increases gestational diabetes risk

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A comprehensive review of nearly 130 studies shows the strongest evidence to date that “forever chemicals” are associated with gestational diabetes, while underscoring uncertainty around other diabetes outcomes and the need for more prospective research. Study: Associations of perfluoroalkyl and polyfluoroalkyl substances with markers of glycaemic control, insulin secretion and sensitivity, and diabetes risk: a … Read more

Women with PCOS face up to sevenfold higher risk of type 2 diabetes: Doctor explains the link

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Polycystic Ovary Syndrome, better known as PCOS, is one of the most common hormone conditions affecting women, but it often hides in plain sight. Many women deal with symptoms for years without ever realizing that PCOS is the reason behind them. Irregular periods, sudden weight changes, skin issues, or constant fatigue can feel random, confusing, … Read more

Continuing Metformin Reduces PCOS Pregnancy Risks

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TOPLINE: Continuing metformin throughout the first trimester in women with polycystic ovary syndrome (PCOS) showed the potential to reduce miscarriage risk (odds ratio [OR], 0.64) and increase clinical pregnancy rates (OR, 1.57) compared with placebo. A meta-analysis of 12 randomized controlled trials involving 1708 women suggested that stopping metformin at pregnancy confirmation might be less … Read more

Back-to-basics, not fad diets beat heart disease and diabetes

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What is the best diet to reduce heart disease and risk of diabetes? Research suggests that a back-to-basics approach may be the key to overcoming the fad diet trend. Study: The impact of dietary interventions on cardiometabolic health. Image credit: New Africa/Shutterstock.com A recent paper published in the journal Cardiovascular Diabetology reviews dietary interventions for cardiometabolic health. An … Read more

Increased prevalence and risk of atherosclerotic cardiovascular disease in individuals with Type 1 diabetes and metabolic dysfunction-associated steatotic liver disease | Cardiovascular Diabetology

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Van der Schueren B, Ellis D, Faradji RN, Al-Ozairi E, Rosen J, Mathieu C. Obesity in people living with type 1 diabetes. Lancet Diabetes Endocrinol. 2021;9(11):776–85. PubMed  Google Scholar  Bielka W, Przezak A, Molęda P, Pius-Sadowska E, Machaliński B. Double diabetes-when type 1 diabetes meets type 2 diabetes: definition, pathogenesis and recognition. Cardiovasc Diabetol. 2024;23(1):62. … Read more

High fat diet disrupts metabolism and increases disease risk

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Consuming a high-fat diet can lead to a variety of health problems – not only weight gain but also an increased risk of diabetes and other chronic diseases. At the cellular level, hundreds of changes take place in response to a high-fat diet. MIT researchers have now mapped out some of those changes, with a … Read more