For people living with human immunodeficiency virus (HIV), life-saving antiretroviral therapy keeps their HIV-infected immune cells from making new copies of the virus, preventing illness and transmission. Historically, these infected cells have been known as the “latent” HIV reservoir-implying that the HIV within the infected cells is completely inactive. But notion that the entirety … Read more
Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous system (CNS) resident macrophages, are key to AD pathology. Indeed, microglia aggregation around amyloid-β (Aβ) deposits is an AD hallmark. Triggering receptor expressed on myeloid cells 2 (TREM2) … Read more
Messenger RNA (mRNA) technology is transforming medicine by providing our cells with genetic instructions to produce proteins that help the immune system prevent or fight a wide range of diseases, including cancer and other rare disorders. Before the molecule can help fight disease, mRNA is packaged into lipid nanoparticles to protect it from rapid degradation. … Read more
A multiomic atlas of the aging human hippocampus uncovers how epigenetic regulation of neural stem cells and immature neurons may shape cognitive decline or resilience in later life. Study: Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease. Image Credit: MP Art / Shutterstock In a recent study published in the journal Nature, researchers delineated neurogenesis … Read more
A new study sheds light on the behavior of yeast cells in the gut, paving the way for new lines of yeast that more efficiently produce therapeutic drugs tailored to address specific diseases. “Yeast is promising as a drug-delivery platform,” says Nathan Crook, corresponding author of the study and an associate professor of chemical and … Read more
The tiny fatty capsules that delivered COVID-19 mRNA vaccines into billions of arms may work better when they’re a little disorganized. That’s the surprising finding from researchers who developed a new way to examine these drug-delivery vehicles one particle at a time-revealing that cramming in more medicine doesn’t always mean better results. The research will … Read more
The brain’s ability to carry out everything from forming memories to coordinating movement depends on its cells producing the right proteins at the right time. But directly measuring this protein production, known as translation, across different types of brain cells has been a challenge. Now, scientists at Scripps Research and UC San Diego have developed … Read more
Researchers from RCSI University of Medicine and Health Sciences have developed a novel implant that delivers tiny growth-promoting particles directly to injured nerve cells, helping them to regrow after spinal cord injury. The study, published in the journal Bioactive Materials, shows how a 3D implant designed to mimic the structure and stiffness of the spinal … Read more
Recent research reveals that nuclear speckles play a key role in modifying viral messenger RNAs and in their transport out of the nucleus; therefore, nuclear speckles are an important subject of study in understanding viral infections. Herpes simplex virus type 1 (HSV-1) infection dramatically remodels the host cell’s nuclear structures. Infection leads to the formation … Read more
A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating an immune response or toxicity-related side effects. Researchers constructed tiny molecular clusters called RNA micelles, loaded them with potent chemo drugs and an … Read more