Apoptosis

Vitamin D curbs colorectal cancer by boosting immunity and blocking tumor growth

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Vitamin D’s anti-cancer powers go beyond bones, new findings reveal how it suppresses inflammation, boosts immune surveillance, and disrupts tumor development to guard against colorectal cancer. Study: Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications. Image Credit: crystal light / Shutterstock.com A recent study in the journal Nutrients reviews the role of vitamin … Read more

Study reveals the role of transcription factors as therapeutic gateways in MAFLD

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Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions worldwide. This complex liver disorder ranges from simple steatosis to more severe forms, including metabolic dysfunction-associated steatohepatitis (MASH), which may progress to fibrosis, cirrhosis, and even liver cancer. The latest insights into transcription factors provide a deeper understanding of the … Read more

Harnessing lncRNAs for early diagnosis and intervention in acute kidney injury

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A new review published in Genes & Diseases on long non-coding RNAs (lncRNAs) highlights their critical role in the development, diagnosis, and potential treatment of acute kidney injury (AKI) and chronic kidney disease (CKD). The findings emphasize the importance of exosomal lncRNAs, which function as molecular regulators in kidney pathology and hold promise for future … Read more

Single-cell analysis reveals key chondrocyte subpopulations in osteoarthritis

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Chondrocytes are specialized cells that are essential for cartilage maintenance and repair, and their dysfunction is central to the development of joint diseases like osteoarthritis (OA). However, the cell heterogeneity of chondrocytes in human articular cartilage is still not well defined, which hinders understanding of the pathogenesis of OA. This research, published in the Genes … Read more

Study reveals ferulic acid’s potential in preventing colon cancer

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Colon cancer continues to be one of the leading causes of cancer-related deaths worldwide, with poor dietary habits identified as a major risk factor. Ferulic acid, a phenolic compound abundant in many plant foods, has previously demonstrated potential anti-cancer properties by inhibiting cell proliferation and promoting apoptosis. Despite its promising effects, the impact of ferulic … Read more

E64FC26 inhibits inflammation and joint destruction in rheumatoid arthritis models

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Background and objectives Protein disulfide isomerases (PDIs) are essential enzymes that facilitate the proper folding of proteins and maintain protein quality within the endoplasmic reticulum. Dysregulation of PDIs has been correlated with numerous disorders, including cancer and rheumatoid arthritis (RA). E64FC26 (EFC), a small molecule that inhibits a wide range of PDI family members, has … Read more

How olive oil bioactives regulate genes linked to insulin resistance

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Review explains how olive oil’s bioactive compounds influence key genetic pathways to improve glucose metabolism, reduce inflammation, and support beta-cell function—offering a natural approach to fighting Type 2 Diabetes. ​​​​​​​Review: Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus. ​​​​​​​Image Credit: sebra / Shutterstock In a recent review published in … Read more

Tiny vesicles offer powerful new approach for cancer treatment

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A new twist on a decades-old anticancer strategy has shown powerful effects against multiple cancer types in a preclinical study from researchers in the Perelman School of Medicine at the University of Pennsylvania. The experimental approach, which uses tiny capsules called small extracellular vesicles (sEVs), could offer an innovative new type of immunotherapy treatment and is poised … Read more