Research highlights rising risk of human-to-human mpox transmission

Mpox has the potential to become a significant global health threat if taken too lightly, according to scientists at the University of Surrey.  In a letter published in Nature Medicine, researchers highlight how mpox – traditionally spread from animals to humans – is now showing clear signs of sustained human-to-human transmission.  Mpox is a viral … Read more

NIH funds research to develop a game-changing HIV diagnostic tool

As of the end of 2023, nearly 40 million people worldwide were living with HIV, including approximately 1.2 million in the United States. In the same year, about 630,000 people globally died from AIDS-related illnesses. Although this is a significant decline from previous years, AIDS-related deaths remain a critical global health challenge. While antiretroviral therapy … Read more

Artificial intelligence tool predicts virus outbreak hotspots

A new artificial intelligence tool could aid in limiting or even prevent pandemics by identifying animal species that may harbor and spread viruses capable of infecting humans. Created by Washington State University researchers, the machine learning model analyzes host characteristics and virus genetics to identify potential animal reservoirs and geographic areas where new outbreaks are … Read more

Red wine lowers bad cholesterol but doesn’t improve overall heart health

A sweeping meta-analysis reveals that while red wine may nudge down LDL cholesterol, its broader heart health benefits remain uncertain—reminding us that moderation and lifestyle still reign supreme. Review: The effects of wine consumption and lipid profile: A systematic review and meta-analysis of clinical trials. Image Credit: Lukas Gojda / Shutterstock Red wine has long been thought … Read more

WHO urges immediate investment of resources to maintain tuberculosis care

On the occasion on World Tuberculosis (TB) Day, marked on 24 March, the World Health Organization (WHO) is calling for an urgent investment of resources to protect and maintain tuberculosis (TB) care and support services for people in need across regions and countries. TB remains the world’s deadliest infectious disease, responsible for over 1 million … Read more

Natural compounds identified as potential inhibitors of SARS-CoV-2 spike protein

The COVID-19 pandemic highlighted the urgent need for effective therapeutic agents against SARS-CoV-2. Although vaccines helped control the spread of the virus, the emergence of new variants continues to challenge global health efforts. Small-molecule inhibitors targeting viral proteins could serve as an effective alternative for controlling the spread of COVID-19 at both individual and community … Read more

Review explores the underlying mechanisms of hepatocarcinogenesis post-HCV eradication

Hepatitis C virus (HCV) infection remains a major global health burden, affecting millions worldwide and contributing significantly to hepatocellular carcinoma (HCC) development. The introduction of direct-acting antivirals (DAAs) has revolutionized HCV treatment, achieving high rates of sustained virologic response (SVR) and reducing HCV-associated morbidity and mortality. Despite these advancements, the risk of HCC persists in … Read more

Coalition of experts reaffirms vaccines as essential for public health

In response to growing concerns over vaccine misinformation, declining public trust in science, and recent outbreaks of preventable diseases, a coalition of 34 scientific and medical organizations, led by the American Association of Immunologists (AAI) and the American College of Physicians (ACP), has issued a unified statement emphasizing the critical role of vaccinations in public … Read more

Tobacco and alcohol use; suicide ideation, plan, and attempt among adolescents; and the role of legal purchase age restrictions: a pooled population-based analysis from 58 countries | BMC Medicine

Participant characteristics A total of 211,022 adolescents (46.7% boys) from 58 countries were included in our analysis. The demographic and behavioral characteristics of the participants are displayed in Table 1. In total, the pooled prevalence rates for suicide ideation, plan, and attempt were 14.9%, 13.5%, and 11.1%, respectively. Among participants who used tobacco, the pooled prevalence … Read more

ASCOLT trial explores aspirin’s role in preventing colorectal cancer recurrence

A large-scale, international, multicentre, phase 3 clinical trial of aspirin for the secondary prevention of colorectal cancer has concluded. Led by Singapore clinician-scientists, the ASCOLT (Aspirin after completion of standard adjuvant therapy for colorectal cancer) trial is the first phase 3 study to assess the efficacy and safety of aspirin in preventing the recurrence of … Read more