in vitro

Breakthrough soft robotics could redefine artificial heart technology

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A groundbreaking soft robotic heart could transform treatment for end-stage heart failure, bringing us closer than ever to fully functional, biocompatible artificial organs. Study: A soft robotic total artificial hybrid heart. Image credit: Africa Studio/Shutterstock.com Researchers developed a total artificial hybrid heart powered by soft robotics, which may open new horizons in heart failure and transplantation medicine. … Read more

Study links neurotensin deficiency to ovulatory dysfunction in PCOS

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Polycystic ovary syndrome (PCOS) represents a significant health concern for women of reproductive age, manifesting as a complex endocrine disorder with diverse clinical presentations. Characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, PCOS affects 5% to 20% of women and stands as a leading cause of anovulatory infertility. The pathophysiology of PCOS involves abnormal … Read more

New automated system revolutionizes drug evaluation in zebrafish

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Preclinical drug evaluation, especially for cardiotoxicity, is a critical stage in the drug development process. Traditional methods, often relying on in vitro assays or manual manipulation of animal models, are both inefficient and unable to fully mimic in vivo conditions. Zebrafish, with their transparent bodies, rapid development, and genetic similarities to humans, are emerging as … Read more

Exploring EGCG’s role in protecting against acetaminophen-induced liver injury

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Announcing a new publication for Acta Materia Medica journal. Excessive consumption of acetaminophen (APAP) has emerged as the primary culprit behind drug-induced liver injury (DILI), with N-acetylcysteine serving as the principal antidote. However, use of N-acetylcysteine is limited to the early stages of APAP-induced DILI and may cause adverse side effects. Consequently, it is imperative … Read more

Adrenomedullin’s role in Obesity-Linked insulin resistance

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A new study uncovers how endothelial cells contribute to insulin resistance in obesity-associated diabetes, highlighting adrenomedullin as a potential therapeutic target. Study: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Image Credit: Kateryna Kon / Shutterstock.com A recent study published in Science investigates the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes. What … Read more

Researchers develop T cell growth method that enhances cancer-fighting ability in melanoma model

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Researchers have developed a new method to grow T cells that have greater longevity and can more efficiently destroy cancer cells in mouse models of melanoma compared to those grown in traditional growth media Study: Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy. Image Credit: ART-ur/Shutterstock.com … Read more

Fluoxetine not effective for COVID-19 patients

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Evidence shows weak antiviral activity and no improvement in symptom outcomes. Study: Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV). Image Credit: luchschenF/Shutterstock.com In a recent study published in eClinicalMedicine, researchers characterized the antiviral activity of a selective serotonin reuptake inhibitor (SSRI), fluoxetine, in early coronavirus disease 2019 (COVID-19). … Read more

Study reveals key antioxidant differences and health benefits

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Scientists show how Manuka and Ohia Lehua honey differ in their antioxidant potential, showing that while Manuka honey boasts higher phenolic content, Ohia Lehua honey excels in reducing oxidative stress and promoting antioxidant defenses. Study: Phytochemical Composition and Antioxidant Activity of Manuka Honey and Ohia Lehua Honey. Image Credit: Valentyn Volkov / Shuttersotck.com The use of … Read more

Gut microbes revealed as hidden drivers of aging and cellular decline

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New research reveals the gut microbiota’s surprising role in aging and highlights promising therapies to counteract its effects on cellular health. Study: Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence. Image Credit: Tatiana Shepeleva / Shutterstock A recent study published in the journal Nature Aging investigated the role of gut microbiota-derived phenylacetylglutamine (PAGln) in driving cellular senescence and … Read more

Insilico Medicine nominates ISM1745 as preclinical candidate for MTAP-deleted cancers.

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Insilico Medicine Advances AI-Powered Drug Discovery with Promising New Candidate for MTAP-Deleted Cancers Insilico Medicine (‘Insilico’), a leading clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, has announced a significant milestone. The company has nominated ISM1745, a novel MTA cooperative PRMT5 inhibitor, as a preclinical candidate (PCC) for the treatment of MTAP-deleted cancers. … Read more