Insulin resistance

Adrenomedullin’s role in Obesity-Linked insulin resistance

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A new study uncovers how endothelial cells contribute to insulin resistance in obesity-associated diabetes, highlighting adrenomedullin as a potential therapeutic target. Study: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Image Credit: Kateryna Kon / Shutterstock.com A recent study published in Science investigates the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes. What … Read more

Your gut bacteria shape your health from childhood to old age, study reveals

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Scientists uncover how your gut bacteria evolve over time—impacting weight, diabetes, and heart health—offering new insights into preventing metabolic diseases. Study: Association between gut microbiome profiles and host metabolic health across the life course: a population-based study. Image Credit: Tatiana Shepeleva / Shutterstock Did you know that over 1 billion people worldwide suffer from metabolic disorders like … Read more

Is Intermittent Fasting Safe and Beneficial?

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Practiced for centuries as a ritual in many religions, intermittent fasting (IF) is rapidly growing in popularity as a weight loss and health-improvement tool. A 2024 survey found that as many as 13% of Americans followed an IF regimen during the previous year. But does it really offer health benefits? And are there any downsides? … Read more

Adrenomedullin hormone contributes to insulin resistance in obesity-associated type 2 diabetes

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The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking adrenomedullin’s effects restores insulin function and improves glucose control in a mouse model, suggesting a potential new target for treating obesity-related metabolic disease. Diabetes is a leading global cause … Read more

How olive oil bioactives regulate genes linked to insulin resistance

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Review explains how olive oil’s bioactive compounds influence key genetic pathways to improve glucose metabolism, reduce inflammation, and support beta-cell function—offering a natural approach to fighting Type 2 Diabetes. ​​​​​​​Review: Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus. ​​​​​​​Image Credit: sebra / Shutterstock In a recent review published in … Read more

Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort study | BMC Infectious Diseases

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Lv Ypin, Cheng P, Zhang J, yu, Mao F, yuan, Teng Y sheng, Liu Y et al. gang,. Helicobacter pylori–induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis. Sci Adv. 2019;5(4):eaau6547. Tsai CC, Kuo TY, Hong ZW, Yeh YC, Shih KS, Du SY, et al. Helicobacter pylori neutrophil-activating protein induces release of histamine and interleukin-6 … Read more

Association of different insulin resistance surrogates with all-cause and cardiovascular mortality among the population with cardiometabolic multimorbidity | Cardiovascular Diabetology

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Forman DE, Maurer MS, Boyd C, Brindis R, Salive ME, Horne FM, Bell SP, Fulmer T, Reuben DB, Zieman S, et al. Multimorbidity in older adults with Cardiovascular Disease. J Am Coll Cardiol. 2018;71(19):2149–61. PubMed  PubMed Central  Google Scholar  Nicholson K, Liu W, Fitzpatrick D, Hardacre KA, Roberts S, Salerno J, Stranges S, Fortin M, … Read more

Muscle fat infiltration predicts heart disease risk better than BMI, study finds

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New research uncovers how fat hidden in your muscles could be a silent threat to your heart, offering a fresh perspective on cardiovascular risk beyond the scale. Study: Skeletal muscle adiposity, coronary microvascular dysfunction, and adverse cardiovascular outcomes. Image Credit: KateStudio / Shutterstock A recent study published in the European Heart Journal examined the role of skeletal muscle fat … Read more

Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study | BMC Gastroenterology

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Chen YC, Malfertheiner P, Yu HT, Kuo CL, Chang YY, Meng FT, Wu YX, Hsiao JL, Chen MJ, Lin KP, Wu CY, Lin JT, O’Morain C, Megraud F, Lee WC, El-Omar EM, Wu MS, Liou JM. Global prevalence of Helicobacter pylori infection and incidence of gastric Cancer between 1980 and 2022. Gastroenterology. 2024;166:605–19. PubMed  Google … Read more

TyG index linked to obesity measures can predict hypertension risk in US adults

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Discover how a simple metabolic marker, the TyG index, combined with obesity measures, can help predict and manage hypertension risk in American adults—offering new hope for cardiovascular health. Study: Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018. Image Credit: Naeblys / Shutterstock In a recent … Read more